Pump solvent recommendations

Follow these solvent recommendations specific to the pump.

• Note: To avoid damaging and clogging components in the wash and purge flow path, Waters recommends not using nonvolatile buffers or additives as wash solvents.
  IPA or organic solvents are effective seal wash solvents for normal-phase separations that employ mobile phases of intermediate polarity (such as hexane or THF). When you use nonvolatile buffers and salts, decrease the seal wash solvent interval (see Wash solvent recommendation for more information about the use of nonvolatile buffer solutions).
• The seal wash system must never run dry, particularly during separations that use a polar mobile phase.
• Ensure that the mobile phase is completely soluble in and compatible with all of the solvents in use on the system (see Wash solvent guidelines).
• For reverse-phase applications, use aqueous seal wash solutions with a weak organic component (for example, 1:9 MeOH/water).