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Solvent considerations

Common solvent properties

Common solvent properties
Topic LCI-USG-0092, Last Updated 11/08/2024

Consult this table for the properties of some common chromatographic solvents.

Table 1. Properties of common solvents
Solvent Vapor pressure mm Hg (Torr) Boiling point (°C) Flash point (°C)
ACN 88.8 at 25 °C 81.6 6
Acetone 184.5 at 20 °C 56.29 -20
n-Butyl acetate 7.8 at 20 °C 126.11 22
n-Butyl alcohol 4.4 at 20 °C 117.5 37
n-Butyl chloride 80.1 at 20 °C 78.44 -9
Chlorobenzene 8.8 at 20 °C 131.69 28
Chloroform 158.4 at 20 °C 61.15 n/a
Cyclohexane 77.5 at 20 °C 80.72 -20
Cyclopentane 400 at 20 °C 49.26 -7
Dimethylacetamide (DMA) 1.3 at 25 °C 166.1 70
DMF 2.7 at 20 °C 153.0 58
DMSO 0.6 at 25 °C 189.0 88
o-Dichlorobenzene 1.2 at 20 °C 180.48 66
Dichloromethane 350 at 20 °C 39.75 n/a
1, 4-Dioxane 29 at 20 °C 101.32 12
Ethyl acetate 73 at 20 °C 77.11 -4
Ethyl alcohol 43.9 at 20 °C 78.32 15
Ethyl ether 442 at 20 °C 34.55 -45
Ethylene dichloride 83.35 at 20 °C 83.48 13
Heptane 35.5 at 20 °C 98.43 -4
Hexane 124 at 20 °C 68.7 -22
IPA 32.4 at 20 °C 82.26 12
Iso-octane 41 at 20 °C 99.24 -12
Isobutyl alcohol 8.8 at 20 °C 107.7 28
Isopropyl myristate <1 at 20 °C 182.6 164
MeOH 97 at 20 °C 64.7 11
Methyl t-butyl ether 240 at 20 °C 55.2 -28
Methyl ethyl ketone 74 at 20 °C 79.64 -9
Methyl isobutyl ketone 16 at 20 °C 117.4 18
N-Methylpyrrolidone 0.33 at 25 °C 202.0 86
Pentane 420 at 20 °C 36.07 -49
n-Propyl alcohol 15 at 20 °C 97.2 23
Propylene carbonate n/a 241.7 135
Pyridine 18 at 25 °C 115.25 20
TEA 57 at 25 °C 89.5 -9
TFA 97.5 at 20 °C 71.8 -3
THF 142 at 20 °C 66.0 -14
Toluene 28.5 at 20 °C 110.62 4
1,2,4-Trichlorobenzene 1 at 20 °C 213.5 106
Water 17.54 at 20 °C 100.0 n/a
o-Xylene 6 at 20 °C 144.41 17

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