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Alliance iS HPLC Systems User Guide
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Alliance iS HPLC Systems User Guide
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Solvent considerations

Solvent viscosity

Solvent viscosity
Topic LCI-USG-0025, Last Updated 11/08/2024

In gradient chromatography, the viscosity changes that occur as the solvents are mixed in varying proportion can affect pressure changes during the run.

Although, generally, viscosity is not a consideration when you use a single solvent or when under low pressure, if you do not know the extent to which pressure changes affect the analysis, monitor the pressure during the run.

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